Radiofrequency in the Management of Colorectal Liver Metastases: A 10-Year Experience at a Single Center
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Abstract: Background: Liver resection is the curative treatment for patients with colorectal liver metastases (CRLMs), with five-year survival rates of 30–50%. Radiofrequency ablation (RFA) is a local and useful alternative for patients with non-resectable CRLMs to obtain complete tumor clearance. The aim of this study was to analyze survival rates with this local treatment. Materials and Methods: All patients who underwent RFA and resection or RFA alone for unresectable CRLMs between 2001 and 2012 were included in a retrospective study. Descriptive and survival statistics were calculated. Morbidity, mortality, and recurrence were also analyzed. Results: The study involved 72 patients and 179 lesions. RFA was performed in 109 procedures. Mortality was 2.7% and morbidity was 25.7%. Local recurrence concerned 25.7% of lesions. Independent risk factors for recurrence were more than one CRLM (p= 0.0427) and size of largest CRLM greater than 3 cm (p= 0.0139). The five-year overall survival rate was 45.5% and the five-year disease-free survival (DFS) was 9.9%. Conclusion: This study shows RFA has good oncological outcomes. The combination of RFA and resection is considered as a curative treatment for patients with unresectable CRLMs. Authors: Dr. Sandra Aissou, MD, Assistant Surgeon, Service de chirurgie viscérale et digestive, Dr. Victoire Cartier, MD, Assistant Radiologist, Service de radiologie interventionnelle, département d'imagerie médicale, Pr. Antoine Hamy, MD, Professor of Surgery, Service de chirurgie viscérale et digestive, Faculté de médecine d'Angers, Dr. Fleur Plumereau, MD, Assistant Surgeon, Service de chirurgie viscérale et digestive, Pr. Christophe Aube, MD, PhD, Professor of Radiology, Service de radiologie interventionnelle, département d'imagerie médicale, Faculté de médecine d'Angers, Pr. Emilie Lermite, MD, PhD, Professor of Surgery, Service de chirurgie viscérale et digestive, Centre Hospitalier Universitaire d'Angers, Faculté de médecine d'Angers, Angers, France |
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